Retinoic Acid Receptor beta antibody (N-Term)

Catalog No. ABIN361388

The Mouse Monoclonal anti-Retinoic Acid Receptor beta antibody has been validated for WB. It is suitable to detect Retinoic Acid Receptor beta in samples from Human.

Quick Overview for Retinoic Acid Receptor beta antibody (N-Term) (ABIN361388)

Target: Retinoic Acid Receptor beta (RARB) (Retinoic Acid Receptor, beta (RARB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoic Acid Receptor beta antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 336

Product Details anti-Retinoic Acid Receptor beta Antibody

Binding Specificity: N-Term

Specificity: Specific for the ~48k RAR-( isotype.

Cross-Reactivity: Human, Rat (Rattus)

Predicted Reactivity: canine, guinea pig, mouse, non-human primate

Purification: Protein G purified culture supernatant

Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH

Isotype: IgG1

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

Target Details for Retinoic Acid Receptor beta

Target: Retinoic Acid Receptor beta (RARB) (Retinoic Acid Receptor, beta (RARB))

Alternative Name: RARB

Background: Retinoic Acid (RA, active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X receptors (RXRs) family (RXRa, ß and () preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs). RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005). Anti- Retinoic Acid Receptor, (-Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~48k RAR-ß isotype.

Molecular Weight: '48 kDa

Gene ID: 5915

UniProt: P10826

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway